Detalhe da pesquisa
1.
Metabolic analysis reveals evidence for branched chain amino acid catabolism crosstalk and the potential for improved treatment of organic acidurias.
Mol Genet Metab
; 128(1-2): 57-61, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31133529
2.
The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
Proc Natl Acad Sci U S A
; 113(52): 15084-15089, 2016 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27956631
3.
A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2.
Hum Mol Genet
; 25(11): 2182-2193, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27053713
4.
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.
Proc Natl Acad Sci U S A
; 112(29): 9088-93, 2015 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26150517
5.
Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.
Mol Ther
; 24(7): 1187-98, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27138040
6.
A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.
J Inherit Metab Dis
; 39(6): 807-820, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27469509
7.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature
; 462(7274): 739-44, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19935646
8.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22922757
9.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature
; 465(7300): 966, 2010 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20559394
10.
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Nat Commun
; 10(1): 96, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30626880
11.
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.
ACS Med Chem Lett
; 9(4): 300-305, 2018 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29670690
12.
Valosin-containing protein phosphorylation at Ser784 in response to DNA damage.
Cancer Res
; 65(17): 7533-40, 2005 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16140914
13.
Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.
Cancer Res
; 65(15): 6593-600, 2005 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16061639
14.
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Cancer Discov
; 7(5): 478-493, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193778
15.
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.
Cell Rep
; 17(3): 876-890, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27732861
16.
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem Cell Reports
; 5(6): 1053-1066, 2015 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26549847
17.
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.
ACS Med Chem Lett
; 3(10): 850-5, 2012 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900389
18.
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.
Chem Biol
; 19(9): 1187-98, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22999886
19.
IDH mutations in glioma and acute myeloid leukemia.
Trends Mol Med
; 16(9): 387-97, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20692206
20.
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.
J Exp Med
; 207(2): 339-44, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20142433